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Unique ID:
#6250
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Price:
$
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Location:
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Posted on:
8th of May 2015 at 7:27 AM
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Expires in:
Expired
Plexxikon, a member of the Daiichi Sankyo Group, is a leader in the discovery and development of novel, small molecule pharmaceuticals. The company utilizes its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical stage compounds in a number of therapeutic areas. Plexxikon’s most advanced program, Zelboraf™ (vemurafenib) was the first oral targeted therapy to be approved for the treatment of both metastatic and unresectable melanomas. Plexxikon’s demonstrated capability in discovery and early development uniquely positions the company to develop multiple commercial franchises for different therapeutic indications, and to create significant value for Plexxikon, Daiichi Sankyo and its collaborators.
Plexxikon’s novel discovery approach, combined with experienced management and scientific teams, a broad network of scientific and clinical experts, and partnerships supporting later stage development, have been key drivers of the company’s success since it began operations in 2001. Plexxikon is a small business with approximately 60 employees based in Berkeley, California. The Scientist will be a critical part of Plexxikon’s research team and will report to the Head of Structural Chemistry.
Responsibilities include, but are not limited to:
•Apply computational strategies to generate structural hypotheses and assist in scaffold discovery and small molecule design
•Develop and adapt new computational chemistry methodologies to improve productivity and accuracy of prediction and maximize the impact of X-ray crystsal structures
•Influence discovery decisions and contribute significantly to corporate goals and project milestones
•Maintain close and effective collaborations with chemists and researchers across disciplines and serve as a resource for colleague in a team environment
•Maintain a command of relevant scientific and patent literature and evaluate implications for internal projects
•Prepare and deliver scientific presentations and reports to communicate complex scientific problems and data to colleagues within and outside structural chemistry department
•Maintain clear, detailed, and up-to-date records of research
•Assume responsibility for maintaining structural bioinformatics and chemical modeling software and computational grid environment and facilitate their use by other scientists
•Other duties, as assigned
Position Requirements & Experience:
•The Scientist 1 level requires a PhD in Structural Biology, Computational Chemistry, Pharmacology, or a closely related field with at least one year of experience in the research environment of a biotech or pharmaceutical company (strong candidates in postdoctoral training will also be considered)
•The Scientist 2 level requires a PhD in Structural Biology, Computational Chemistry, Pharmacology, or a closely related field with at least three years of experience in the research environment of a biotech or pharmaceutical company
•Experience with iterative structure-guided lead generation with track record of success
•In-depth knowledge of the principles of protein structure and medicinal chemistry and broad experience in late stage lead optimization of ADME/Tox properties
•Experience with combinatorial library design, 3D pharmacophore/docking approaches, molecular dynamics simulations, free energy methods, QM/electronic structure calculation, and small molecule conformational analysis
•Programming experience in Perl, Python, and/or C/C++
•A track record of accomplishments (including patent and literature publications) demonstrating technical proficiency, independent thinking and scientific creativity
•Self-motivated with the ability to work independently and effectively
•Effective in mining computational, chemical and other scientific literature
•Exhibit flexibility and adaptability as projects and goals shift
•Demonstrated ability to work on multiple projects simultaneously
•Excellent verbal and written communication skills are essential in this collaborative work environment
Plexxikon, an equal opportunity employer, is located in Berkeley, just off interstate 80. We offer a chance to work with talented people in a collaborative environment and provide top-notch benefits including health insurance, generous time off and much more. To learn more about Plexxikon, please visit our website at www.plexxikon.com.
If you are interested in applying for this opportunity, please submit your resume or CV, cover letter and salary requirements. All submissions will be evaluated and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.
No Phone Calls
No Agencies or Recruiters
Apply Here
http://www.jobscore.com/jobs2/plexxikon/scientist-1-or-2-computational-chemistry/bqEUE09dyr5l6ziGaltGfR?Board=CraigsList&PID=2282368
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